NFL Week 4 Odds and Betting Lines: Lions Favored at Home Over Seahawks

Green Day asked that we "wake them up when September ends," but then they'd miss out on the NFL Week 4 odds.

The first month of the schedule closes with an exciting slate of betting matchups. With Sunday's slate done or in progress, the NFL odds for Week 4 are headlined by a Monday Night Football double-feature: Titans at Dolphins and Seahawks at Lions.

I break down the NFL Week 4 odds and all the early line movement below.

NFL Week 4 Odds

These are the NFL odds for Week 4, highlighted by the two more games on Monday Night Football. 

Matchup	Time (E.T.)	Odds
Cowboys vs Giants	Thursday 8:15 p.m. Prime	Giants +6 O/U 45.5
Steelers vs  Colts	Sunday 1:00 p.m. CBS	Colts +2 O/U 40
Vikings vs Packers	Sunday 1:00 p.m. CBS	Packers -2.5 O/U 43.5
Jaguars vs Texans	Sunday 1:00 p.m. CBS	Texans -6 O/U 44.5
Saints vs Falcons	Sunday 1:00 p.m. FOX	Falcons -3 O/U 41
Rams vs Bears	Sunday 1:00 p.m. FOX	Bears -3 O/U 40.5
Eagles vs Buccaneers	Sunday 1:00 p.m. FOX	Buccaneers +1 O/U 42.5
Bengals vs Panthers	Sunday 1:00 p.m. FOX	Panthers +4.5 O/U 47.5
Broncos vs Jets	Sunday 1:00 p.m. CBS	Jets -8 O/U 39.5
Commanders vs Cardinals	Sunday 4:05 p.m. FOX	Cardinals -3.5 O/U 49
Patriots vs 49ers	Sunday 4:05 p.m. FOX	49ers -10.5 O/U 40.5
Browns vs Raiders	Sunday 4:25 p.m. CBS	Raiders +2 O/U 36.5
Chiefs vs Chargers	Sunday 4:25 p.m. CBS	Chargers +7 O/U 39.5
Bills vs  Ravens	Sunday 8:20 p.m. NBC	Ravens -2.5 O/U 46.5
Titans vs  Dolphins	Monday 7:30 p.m. ESPN	Dolphins -1.5 O/U 37
Seahawks vs Lions	Monday 8:15 p.m. ABC	Lions -3.5 O/U 46.5

Lines courtesy of BetMGM as of 9-28.

Steelers vs. Colts odds

Opening line

• Colts +1.5
• Over/Under 40
• View full Steelers vs. Colts odds and matchup
• Read our Steelers vs. Colts picks and predictions

The look-ahead line has the Colts as 1.5-point home chalk but the official Week 4 opener jumps the fence, with Pittsburgh hitting the board at -1.5. This spread is now up to -2.5 on Sunday morning. The total opened as high as 40 points and quickly drew Under money, dropping the number to as short as 38.5. That has since rebounded to as high as 40.5 O/U.

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Vikings vs. Packers odds

Opening line

• Packers -2
• Over/Under 43.5
• View full Vikings vs. Packers odds and matchup
• Read our Vikings vs. Packers picks and predictions

Green Bay opened as a 2-point favorite, leaning toward Jordan Love being under center. As of Sunday morning, the Packers are now favored by -3 at most books. However, Minnesota is looking very good at 3-0, especially on defense. This total opened at 43.5 O/U and is up to 44 points.

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Jaguars vs. Texans odds

Opening line

• Texans -6
• Over/Under 45.5
• View full Jaguars vs. Texans odds and matchup
• Read our Jaguars vs. Texans picks and predictions

Jacksonville is on a short week and back on the road after getting blasted in Buffalo on Monday. The look-ahead line was as low as Texans -4.5 but the official Week 4 opener was up to -6 with Houston -6.5 widely available on Thursday. However, that spread has dropped below the key number and sits as low as Texans -5 on Sunday morning. Jacksonville's offensive woes trimmed the total to as low as 44.5 O/U.

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Saints vs. Falcons odds

Opening line

• Falcons -1.5
• Over/Under 45.5
• View full Saints vs. Falcons odds and matchup
• Read our Saints vs. Falcons picks and predictions

The Saints' explosive offense came back to earth in Week 3 and now New Orleans is a 3-point road underdog at Atlanta in Week 4. The Falcons gave Kansas City a fight on Sunday night, with some controversial calls keeping them from pulling off the upset. This total opened at 45.5 O/U and has cratered to as low as 40.5, but there are some 42-point totals on the board Sunday morning.

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Rams vs. Bears odds

Opening line

• Bears -1.5
• Over/Under 40.5
• View full Rams vs. Bears odds and matchup
• Read our Rams vs. Bears picks and predictions

Chicago was a 3-point favorite on the look-ahead lines but with the offense struggling, this spread was hacked in half with the Bears laying -1.5 at home to Los Angeles at open. That number is back up to Bears -3 on Sunday morning. The Rams are ravaged by injuries but snuck out an upset win over the rival 49ers in Week 3. The total opened at 40.5 O/U and remains as such.

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Eagles vs. Buccaneers odds

Opening line

• Buccaneers +2.5
• Over/Under 46
• View full Eagles vs. Buccaneers odds and matchup
• Read our Eagles vs. Buccaneers picks and predictions

Philadelphia pulled out of its tailspin with a comeback win in New Orleans in Week 3. The Eagles are 1-point favorites in Tampa Bay, with the Bucs coming off an upset loss to Denver. The Over/Under opened between 45 and 46 points and is down to 42 O/U on Sunday morning. The Eagles have injuries piling up on the offensive line and will be down WRs DeVonta Smith and A.J. Brown.

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Bengals vs. Panthers odds

Opening line

• Panthers +4.5
• Over/Under 47.5
• View full Bengals vs. Panthers odds and matchup
• Read our Bengals vs. Panthers picks and predictions

The Bengals burned bettors again, losing outright as 7.5-point home chalk to Washington on Monday. That has knocked the look-ahead line down a point from Cincinnati -5.5 to -4.5. The total was up to 48.5 with Andy Dalton giving new life to Carolina's offense and the Bengals' defense coming off a short week, but it has since dipped to 47.5 on Sunday.

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Broncos vs. Jets odds

Opening line

• Jets -7.5
• Over/Under 38.5
• View full Broncos vs. Jets odds and matchup
• Read our Broncos vs. Jets picks and predictions

New York had a mini-bye to build on its win last Thursday. Oddsmakers opened the Jets as 7.5-point favorites hosting the Broncos, who could be ripe for a letdown after an upset at Tampa Bay in Week 3. This spread is a consensus -8 on Sunday morning. The total opened at 38.5 points and as gained a full point across the board at 39.5 O/U.

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Commanders vs. Cardinals odds

Opening line

• Cardinals -3.5
• Over/Under 50.5
• View full Commanders vs. Cardinals odds and matchup
• Read our Commanders vs. Cardinals picks and predictions

What looked like a dud of a Week 4 game when the schedule was released could be the most exciting matchup on the board. The tall total thinks so, with this Over/Under opening at 50.5 (now 49) following Washington's explosive upset over Cincinnati on Monday. Arizona was -4.5 on the look-ahead spread but the official Week 4 opener is Cardinals -3.5.

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Patriots vs. 49ers odds

Opening line

• 49ers -10.5
• Over/Under 40
• View full Patriots vs. 49ers odds and matchup
• Read our Patriots vs. 49ers picks and predictions

Even with New England holding the rest edge and the injury-plagued 49ers coming off a loss, books went big on San Francisco. The Niners opened as 10.5-point favorites and that is as high as -11 on Sunday morning. Receiver Deebo Samuel and OT Trent Williams are leaning toward playing in Week 4. The Over/Under opened at 40 points, ticked down to 39-39.5 and has jumped back to 40.5 on Sunday. 

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Browns vs. Raiders odds

Opening line

• Raiders +1
• Over/Under 39
• View full Browns vs. Raiders odds and matchup
• Read our Browns vs. Raiders picks and predictions

This spread was bouncing around a pick'em at some books with others opening Cleveland as a 1-point road favorite. Las Vegas quickly took money and ran to a short favorite before ruling WR Davonte Adams out for Week 4, pushing the spread to Browns -2.5 on Sunday morning. The total is one of the lowest on the board, at 36.5 O/U.

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Chiefs vs. Chargers odds

Opening line

• Chargers +8.5
• Over/Under 39.5
• View full Chiefs vs. Chargers odds and matchup
• Read our Chiefs vs. Chargers picks and predictions

With a long list of injuries stacking for the Chargers, oddsmakers opened Kansas City as an 8.5-point favorite on the road in Week 4. The spread was all over the place, ranging from a low of -7.5 to a high of -9.5 before books settled on KC -7. Chargers QB Justin Herbert is expected to play in Week 4. That's bumped this total from a low of 39.5 to as many as 42 points on Sunday morning.

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Bills vs. Ravens odds

Opening line

• Ravens -1.5
• Over/Under 46.5
• View full Bills vs. Ravens odds and matchup
• Read our Bills vs. Ravens picks and predictions

Even a one-sided win over Jacksonville on Monday night can't budge the spread for this huge AFC outing. Baltimore is a 2.5-point home chalk for Sunday Night Football, with the total staying between 45.5 and 46.5.

Also see: full Sunday Night Football odds

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Titans vs. Dolphins odds

Opening line

• Dolphins -1.5
• Over/Under 37.5
• View full Titans vs. Dolphins odds and matchup
• Read our Titans vs. Dolphins picks and predictions (coming soon)

Tennessee opened between -1 and +1.5 for this Monday matchup with Miami. The market has come back on the Dolphins, with recently signed QB Tyler Huntley getting the start in Week 4. That has the spread at Miami -2.5 on Sunday morning. This total is down to between 36.5 and 37.5 points.

Also see: full Monday Night Football odds

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Seahawks vs. Lions odds

Opening line

• Lions -4.5
• Over/Under 48.5
• View full Seahawks vs. Lions odds and matchup
• Read our Seahawks vs. Lions picks and predictions

Both teams were victorious in Week 3, with Detroit opening as a 4.5-point home favorite. Most operators were down to -3.5 with injuries to the Lions slimming that spread, but it's since rebounded to the opening number at several books on Sunday evening. This total opened at 48.5 points and is down as low as 46.5 points on Sunday.  

Also see: full Monday Night Football odds

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More weekly NFL odds content

• Week 1 odds
• Week 2 odds
• Week 3 odds
• Week 5 odds
• Week 6 odds
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• Week 8 odds
• Week 9 odds
• Week 10 odds
• Week 11 odds
• Week 12 odds
• Week 13 odds
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• Week 18 odds

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